Serum hormonal levels in HIV/AIDS infected male subjects on antiretroviral therapy (ART) in Nnewi, Nigeria

This study was designed to assess the serum hormonal levels (Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Testosterone, Estrogen, Progesterone, Prolactin and Cortisol) in symptomatic HIV/AIDS male subjects on ART. A total of 411 participants aged between 17 and 58 (43 ±10) years were randomly recruited for the study. The participants were staged and grouped as follows: symptomatic HIV/AIDS male subjects on ART (n= 139), symptomatic HIV/AIDS male subjects not on ART (n= 136) and HIV seronegative subjects (n= 136). Blood samples were collected from the participants for the determination of HIV status by immunochromatography and HIV confirmation by Western Blot. Enzyme Linked Immunosorbent assay (ELISA) was used to assay for FSH, LH, Testosterone, Estrogen, Progesterone, Prolactin and Cortisol levels. Their results showed significant rise in FSH, LH in HIV seropositive participants on ART compared respectively to those not on ART and the HIV seropositive subjects (p< 0.05). On the other hand, the Estrogen, Progesterone, Prolactin and Cortisol were all raised in symptomatic HIV seropositive participants not on ART compared respectively to the symptomatic HIV seroposive on ART and the HIV seronegative groups (p< 0.05). The testosterone levels significantly decreased in both symptomatic HIV infected subjects on ART and those not on ART compared with the HIV seronegative controls (p< 0.05). The relevance of HIV infection on the serum hormonal status is that HIV infection causes hypogonadism as well as primary testicular failure in symptomatic HIV participants not on ART. Also, HIV infection causes hyperprolactinaemia, hyperprogesteronaemia and hypercortisolism in symptomatic HIV participants not on ART. © 2012 International Formulae Group. All rights reserved.